The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2020
Filed:
Oct. 10, 2017
Northwestern University, Evanston, IL (US);
Richard B. Silverman, Winnetka, IL (US);
Hoang V. Le, Oxford, MS (US);
Rima L. McLeod, Chicago, IL (US);
Dustin D. Hawker, Evanston, IL (US);
Northwestern University, Evanston, IL (US);
Abstract
Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection byand toxoplasmosis and for treating infection byand malaria. The compounds disclosed herein are observed to selectively inactivateornithine aminotransferase (TgOAT) relative to human OAT and relative to human γ-aminobutyric aminotransferase (GABA-AT).