The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2020
Filed:
May. 19, 2015
Applicant:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Inventor:
Soner Altiok, Tampa, FL (US);
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5088 (2013.01); G01N 33/57484 (2013.01); C12Q 2600/158 (2013.01); G01N 2570/00 (2013.01); G01N 2800/52 (2013.01); G01N 2800/60 (2013.01);
Abstract
A method of determining disease diagnosis, progression and response to therapy through the use of xenograft animal models for determining cancer biomarkers is presented. In use, a tumor from a patient is transplanted into an animal model such as a mouse. Expression levels of biomarkers for a disease are assessed in the serum of the animal model. A personalized gene expression profile or biomarker gene signature may be obtained from the expression levels of the biomarkers which can be used to determine disease recurrence, progression and response to therapy.