The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2020
Filed:
Oct. 05, 2016
Applicant:
National Research Council of Canada, Ottawa, CA;
Inventors:
Jianbing Zhang, Ottawa, CA;
Tomoko Hirama, Tokyo, JP;
Assignee:
National Research Council of Canada, Ottawa, CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/557 (2006.01); C12N 15/62 (2006.01); G01N 33/68 (2006.01); C07K 14/765 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
G01N 33/557 (2013.01); C07K 14/765 (2013.01); C07K 16/283 (2013.01); C12N 15/62 (2013.01); G01N 33/6803 (2013.01); C07K 2317/21 (2013.01); C07K 2317/22 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/74 (2013.01);
Abstract
Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides s method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously. PCs are fused to a protein anchor, which is captured by the target/antigen. The captured PCs are evaluated for their expression levels, biophysical properties and affinities using conventional methods.