The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2020
Filed:
Jul. 04, 2014
Applicant:
Biontech Ag, Mainz, DE;
Inventor:
Steve Pascolo, Zürich, CH;
Assignee:
BioNTech AG, Mainz, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/117 (2010.01); A61K 47/26 (2006.01); A61K 9/00 (2006.01); A61K 47/64 (2017.01); A61K 47/69 (2017.01); A61K 39/39 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/117 (2013.01); A61K 9/0019 (2013.01); A61K 39/39 (2013.01); A61K 47/26 (2013.01); A61K 47/6455 (2017.08); A61K 47/6931 (2017.08); A61K 48/0041 (2013.01); A61K 2039/55561 (2013.01); C12N 2310/17 (2013.01); C12N 2310/351 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present invention relates to stable low-salt aqueous formulations of particles comprising a polycation, preferably protamine, and RNA, which formulations are preferably isotonic, to pharmaceutical compositions or kits comprising such formulations and to their use in medicine. It further relates to methods for preparing the formulations of the invention and to methods for physically stabilizing particles comprising a polycation, preferably protamine, and RNA.