logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10626387 B1

PDFFull Text
Date of Patent:
Apr. 21, 2020

Filed:

Apr. 12, 2016

Staphylococcus lysin and use thereof

Applicant:

Phagelux, Inc., Grand Cayman, KY;

Inventors:

Hongping Wei, Wuhan, CN;

Hang Yang, Wuhan, CN;

Junping Yu, Wuhan, CN;

Assignee:

Phagelux, Inc., Grand Cayman, KY;

Attorney:

Viksnins Harris Padys Malen LLP

Primary Examiner:

Nita M Minnifield

Int. Cl.
CPC ...
C12N 9/36 (2006.01); C12N 15/70 (2006.01); C12N 15/62 (2006.01); C12N 9/48 (2006.01); C12Q 1/68 (2018.01); A61K 38/51 (2006.01); C12Q 1/66 (2006.01); C12Q 1/14 (2006.01); C12Q 1/527 (2006.01); C12N 9/88 (2006.01); C12N 9/80 (2006.01); C12N 1/06 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/689 (2018.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2462 (2013.01); A61K 38/51 (2013.01); C12N 1/06 (2013.01); C12N 9/485 (2013.01); C12N 9/80 (2013.01); C12N 9/88 (2013.01); C12N 15/62 (2013.01); C12N 15/70 (2013.01); C12Q 1/14 (2013.01); C12Q 1/527 (2013.01); C12Q 1/66 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/689 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention discloses a lysin that is capable of killingand the use thereof, belonging to the field of biological agents. The present invention discloses the amino acid sequence and the encoding gene sequence of the lysin. This lysin keeps active in a wide range of pH. It has lytic activity againstin pH 4-11. The recombinant protease constructed by the encoding gene can be solubly expressed instrain BL21 (DE3). The lysin can be used to effectively kill multiple speciesin vitro, including methicillin sensitive(MSSA) and methicillin resistant(MRSA) isolated in clinics. This lysin can be used as an antibiotic for the treatment of staphylococcal infections in vivo. This lysin is also able to rapidly lyse staphylococcal cell wall; as a result, intracellular substances such as ATP and DNA are released. Those released substances can be used to detect the type of

Find Patent Forward Citations

Loading…