The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2020
Filed:
Feb. 08, 2017
Applicant:
University of Rochester, Rochester, NY (US);
Inventors:
Steven A. Goldman, Webster, NY (US);
Su Wang, Rochester, NY (US);
Assignee:
University of Rochester, Rochester, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/02 (2006.01); C12N 5/071 (2010.01); C12N 5/079 (2010.01); A61K 9/00 (2006.01); A61K 35/30 (2015.01); C12N 5/0735 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0622 (2013.01); A61K 9/0085 (2013.01); A61K 35/30 (2013.01); C12N 5/0606 (2013.01); C12N 2506/02 (2013.01); C12N 2506/094 (2013.01); C12N 2506/45 (2013.01);
Abstract
The present disclosure relates to methods of producing a preparation of CD140a/PDGFRα positive cells from pluripotent cells, where the preparation comprises oligodendrocyte progenitor cells co-expressing OLIG2 and CD140a/PDGFRα. The cell preparation has an in vivo myelination efficiency that is equal to or greater than the in vivo myelination efficiency of a preparation of A2B5/PSA-NCAMsorted fetal human tissue derived oligodendrocyte progenitor cells. Methods of enriching and therapeutic uses of the disclosed cell preparation are also described.