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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10626369 B1

PDFFull Text
Date of Patent:
Apr. 21, 2020

Filed:

Feb. 08, 2017

Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders

Applicant:

University of Rochester, Rochester, NY (US);

Inventors:

Steven A. Goldman, Webster, NY (US);

Su Wang, Rochester, NY (US);

Assignee:

University of Rochester, Rochester, NY (US);

Attorney:

Pepper Hamilton LLP

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
C12N 5/02 (2006.01); C12N 5/071 (2010.01); C12N 5/079 (2010.01); A61K 9/00 (2006.01); A61K 35/30 (2015.01); C12N 5/0735 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0622 (2013.01); A61K 9/0085 (2013.01); A61K 35/30 (2013.01); C12N 5/0606 (2013.01); C12N 2506/02 (2013.01); C12N 2506/094 (2013.01); C12N 2506/45 (2013.01);
Abstract

The present disclosure relates to methods of producing a preparation of CD140a/PDGFRα positive cells from pluripotent cells, where the preparation comprises oligodendrocyte progenitor cells co-expressing OLIG2 and CD140a/PDGFRα. The cell preparation has an in vivo myelination efficiency that is equal to or greater than the in vivo myelination efficiency of a preparation of A2B5/PSA-NCAMsorted fetal human tissue derived oligodendrocyte progenitor cells. Methods of enriching and therapeutic uses of the disclosed cell preparation are also described.

Find Patent Forward Citations

Goldman, Steven. (2020). Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders (U.S. Patent No. 10626369). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10626369

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