The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2020
Filed:
May. 05, 2016
Ustav Makromolekularni Chemie Av Cr, V.v.i., Prague—Brevnov, CZ;
Ustav Fotoniky a Elektroniky Av Cr, V.v.i., Prague, CZ;
Cesar Rodriguez-Emmenegger, Prague, CZ;
Frantisek Surman, Velke Popovice, CZ;
Eduard Brynda, Prague, CZ;
Tomas Riedel, Prague, CZ;
Milan Houska, Prague, CZ;
Hana Lisalova, Prague, CZ;
Jiri Homola, Prague, CZ;
USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., Brevnov, CZ;
Abstract
The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure IS—R-polymer  (I) Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.