The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2020

Filed:

May. 21, 2015
Applicant:

Entrada Therapeutics, Inc., Boston, MA (US);

Inventors:

Dehua Pei, Columbus, OH (US);

Ziqing Qian, Columbus, OH (US);

Assignee:

ENTRADA THERAPEUTICS, INC., Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/64 (2006.01); C07K 7/06 (2006.01); A61K 47/64 (2017.01); A61K 38/05 (2006.01); A61K 38/12 (2006.01); A61K 38/46 (2006.01); A61K 49/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); A61K 38/05 (2013.01); A61K 38/12 (2013.01); A61K 38/465 (2013.01); A61K 47/64 (2017.08); A61K 49/0039 (2013.01); A61K 49/0041 (2013.01); A61K 49/0043 (2013.01); A61K 49/0047 (2013.01); A61K 49/0056 (2013.01); C07K 7/06 (2013.01); C12Y 301/03048 (2013.01); A61K 38/00 (2013.01);
Abstract

Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and a cargo moiety. The cargo moiety can comprise one or more detectable moieties, one or more therapeutic moieties, one or more targeting moieties, or any combination thereof. In some examples, the cell penetrating peptide moiety is cyclic. In some examples, the cell penetrating peptide moiety and cargo moiety together are cyclic. In some examples, the cell penetrating peptide moiety is cyclic and the cargo moiety is appended to the cyclic cell penetrating peptide moiety structure. In some examples, the cargo moiety is cyclic and the cell penetrating peptide moiety is cyclic, and together they form a fused bicyclic system.


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