The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2020

Filed:

Apr. 03, 2018
Applicants:

Jonathan C. Evans, Midland, MI (US);

Derrick D. Hilliker, Midland, MI (US);

Theodore W. Selby, Midland, MI (US);

Inventors:

Jonathan C. Evans, Midland, MI (US);

Derrick D. Hilliker, Midland, MI (US);

Theodore W. Selby, Midland, MI (US);

Assignee:

Tannas Company, Midland, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 25/20 (2006.01); G01N 25/22 (2006.01); G01N 25/26 (2006.01); G01N 33/15 (2006.01); B01J 19/00 (2006.01); B01J 19/02 (2006.01); G01N 31/00 (2006.01); B01L 9/06 (2006.01); G01N 35/00 (2006.01); B01L 7/00 (2006.01); B01L 1/02 (2006.01);
U.S. Cl.
CPC ...
B01J 19/0013 (2013.01); B01J 19/02 (2013.01); B01L 9/06 (2013.01); G01N 25/20 (2013.01); G01N 25/22 (2013.01); G01N 25/26 (2013.01); G01N 31/00 (2013.01); G01N 33/15 (2013.01); B01J 2219/00011 (2013.01); B01J 2219/00132 (2013.01); B01L 1/025 (2013.01); B01L 7/52 (2013.01); B01L 2200/147 (2013.01); B01L 2400/0409 (2013.01); G01N 2035/00099 (2013.01);
Abstract

An active pharmaceutical ingredients (API) or related substance (RS) can be tested for stability by placing the API or RS in an instrument containing a pressure-controllable atmosphere, controlling the pressure of the atmosphere in the instrument for a predetermined time, and evaluating the API or RS for stability. Testing can be carried out also at predetermined temperature(s) and/or under the influence of gaseous trigger(s) and so forth. For instance, an API sample can be placed in a bomb test instrument/reactor, oxygen as a gaseous trigger can be introduced to contact the API sample under constant and/or ramped temperature(s) and elevated pressure(s) for predetermined time(s), and the API sample can be evaluated for stability. An insert carousel may hold a sample of API(s) and/or RS(s) and/or aliquot(s) of sample(s) of API(s) and/or RS(s) for insertion into the bomb test instrument/reactor.


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