The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2020
Filed:
Jul. 12, 2018
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Demetrios Braddock, Guilford, CT (US);
Ronald Albright, Guilford, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2006.01); C12N 9/14 (2006.01); C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
A61K 38/465 (2013.01); A61K 38/46 (2013.01); C12N 9/14 (2013.01); C12N 9/16 (2013.01); C12Y 301/04001 (2013.01); C12Y 306/01009 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.