The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2020

Filed:

Jun. 18, 2018
Applicant:

Creative Bio-peptides Inc., Potomac, MD (US);

Inventor:

Michael R. Ruff, Potomac, MD (US);

Assignee:

Creative Bio-Peptides Inc., Potomac, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2019.01); A61K 38/00 (2006.01); A61P 1/16 (2006.01); C07K 7/06 (2006.01); C07K 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/08 (2013.01); A61P 1/16 (2018.01);
Abstract

A method of treating liver inflammation in an individual caused by excess fat deposition, sometimes called 'fatty liver disease', which may be caused by metabolic syndrome, insulin resistance, or gut microbial dysbiosis, and which may lead to the serious and potentially life-threatening condition of non-alcoholic steatohepatitis (NASH). A composition composed of an all-D amino acid peptide and a pharmaceutically acceptable carrier is prepared and administered to a patient. The D peptide has the general structure: A-B-C-D-E in which The composition acts to suppress inflammation underlying steatohepatitis. The D peptide may be esterified, glycosylated, or amidated at E to enhance tissue distribution by promoting egress from the circulation and penetration into the liver.


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