IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10624882 B1

PDFFull Text
Date of Patent:
Apr. 21, 2020

Filed:

Dec. 29, 2017

Rho kinase inhibitors

Applicant:

Aerie Pharmaceuticals, Inc., Irvine, CA (US);

Inventors:

Todd Bosanac, New Milford, CT (US);

John David Ginn, New Milford, CT (US);

Eugene Richard Hickey, Ridgefield, CT (US);

Thomas Martin Kirrane, Jr., Middlebury, CT (US);

Weimin Liu, Sandy Hook, CT (US);

Anthony S. Prokopowicz, Stormville, NY (US);

Sabine K. Schlyer, New Milford, CT (US);

Cheng-Kon Shih, Danbury, CT (US);

Roger John Snow, Danbury, CT (US);

Michael Robert Turner, Danbury, CT (US);

Frank Wu, Ridgefield, CT (US);

Erick Richard Young, Danbury, CT (US);

Assignee:

Aerie Pharmaceuticals, Inc., Bedminster, NJ (US);

Attorneys:

K&L Gates LLP

Louis C. Cullman

Benjamin D. Heuberger

Primary Examiner:

David K O'Dell

Int. Cl.
CPC ...
C07D 487/08 (2006.01); A61K 31/472 (2006.01); A61K 31/517 (2006.01); C07D 239/88 (2006.01); C07D 239/90 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); A61P 9/00 (2006.01); A61P 27/06 (2006.01); C07D 217/24 (2006.01); C07D 401/12 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01);
U.S. Cl.
CPC ...
A61K 31/472 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61P 9/00 (2018.01); A61P 27/06 (2018.01); C07D 217/24 (2013.01); C07D 239/88 (2013.01); C07D 239/90 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 487/08 (2013.01);
Abstract

Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

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