The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 21, 2020

Filed:

Oct. 10, 2018
Applicant:

Pathak Holdings Llc, Phoenix, AZ (US);

Inventor:

Chandrashekhar P. Pathak, Phoenix, AZ (US);

Assignee:

Pathak Holdings LLC, Phoenix, AZ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/155 (2006.01); A61K 31/7036 (2006.01); A61K 31/496 (2006.01); A61K 9/00 (2006.01); A61K 47/34 (2017.01); A61K 41/00 (2020.01); A61K 9/16 (2006.01); A61L 27/50 (2006.01); A61K 31/727 (2006.01); A61K 31/337 (2006.01); A61M 37/00 (2006.01); A61K 31/573 (2006.01); A61K 31/37 (2006.01); A61L 27/38 (2006.01); A61K 47/32 (2006.01); A61K 9/06 (2006.01); A61L 27/22 (2006.01); A61K 9/50 (2006.01); A61M 5/32 (2006.01); A61K 47/02 (2006.01); A61L 27/54 (2006.01); A61M 5/30 (2006.01);
U.S. Cl.
CPC ...
A61K 31/155 (2013.01); A61K 9/0014 (2013.01); A61K 9/0021 (2013.01); A61K 9/0024 (2013.01); A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 9/06 (2013.01); A61K 9/1641 (2013.01); A61K 9/1647 (2013.01); A61K 9/1658 (2013.01); A61K 9/5031 (2013.01); A61K 9/5052 (2013.01); A61K 31/337 (2013.01); A61K 31/37 (2013.01); A61K 31/496 (2013.01); A61K 31/573 (2013.01); A61K 31/7036 (2013.01); A61K 31/727 (2013.01); A61K 41/0028 (2013.01); A61K 47/02 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61L 27/225 (2013.01); A61L 27/3804 (2013.01); A61L 27/50 (2013.01); A61M 5/3298 (2013.01); A61M 37/0015 (2013.01); A61M 37/0076 (2013.01); A61L 27/54 (2013.01); A61L 2300/442 (2013.01); A61L 2400/06 (2013.01); A61M 5/3015 (2013.01); A61M 2037/003 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0046 (2013.01); A61M 2037/0053 (2013.01); A61M 2205/36 (2013.01); A61M 2205/3606 (2013.01); A61M 2205/3633 (2013.01); A61M 2205/3653 (2013.01); A61M 2207/00 (2013.01); C12Y 304/21068 (2013.01); C12Y 304/24069 (2013.01);
Abstract

Methods and compositions are for preparing microimplant arrays for sustained drug delivery or live cell based therapy. The 'array in array' (AIA) device enables formation of microimplant arrays without having tissue piercing elements to the microimplant. The methods and compositions are for solid state delivery of drugs, especially biologics drugs without forming a drug solution prior to injection. New methods and compositions are for preparing in situ arrays for sustained drug delivery or live cell based therapy. Tissue surface is first treated with laser drilling, microneedle array, mechanical drilling or other methods to create artificial micro-porosity of various sizes, shapes and patterns. The artificial pores created are then infused with sustained drug delivery compositions or live cell suspensions. The compositions are converted into solid or semisolid state by physical or chemical reaction/s to entrap drug or live cells. The entrapped drug or live cells provide local or systemic therapeutic benefit.


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