The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Jan. 02, 2019
Cell2in, Inc., Seoul, KR;
Korea University Research and Business Foundation, Seoul, KR;
Snu R&db Foundation, Seoul, KR;
In-Gyu Kim, Incheon, KR;
Ki Hang Choi, Seoul, KR;
Eui Man Jeong, Seoul, KR;
Heun Soo Kang, Gyeonggi-do, KR;
Cell2In, Inc., , KR;
Korea University Reserach and Business Foundation, , KR;
SNU R&DB Foundation, , KR;
Abstract
The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.