The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
May. 05, 2017
Quest Diagnostics Investments Incorporated, Wilmington, DE (US);
Somalogic, Inc., Boulder, CO (US);
Chris Bock, Denver, CO (US);
Deborah Ayers, Broomfield, CO (US);
Malti P. Nikrad, Boulder, CO (US);
Bharat Nathu Gawande, Lafayette, CO (US);
Jennifer C. Bertino, Arvada, CO (US);
Weimin Sun, Irvine, CA (US);
Charles M. Strom, San Clemente, CA (US);
Noh Jin Park, San Juan Capistrano, CA (US);
Quest Diagnostics Investments Incorporated, Wilmington, DE (US);
Somalogic, Inc., Boulder, CO (US);
Abstract
The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3' cap. In some embodiments, the 3′ cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5′-end of the aptamer and the moiety is attached the 5′ end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.