The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Mar. 30, 2012
Tomoyuki Igawa, Shizuoka, JP;
Atsuhiko Maeda, Shizuoka, JP;
Kenta Haraya, Shizuoka, JP;
Yuki Iwayanagi, Shizuoka, JP;
Tatsuhiko Tachibana, Shizuoka, JP;
Futa Mimoto, Shizuoka, JP;
Taichi Kuramochi, Shizuoka, JP;
Hitoshi Katada, Shizuoka, JP;
Shojiro Kadono, Kanagawa, JP;
Tomoyuki Igawa, Shizuoka, JP;
Atsuhiko Maeda, Shizuoka, JP;
Kenta Haraya, Shizuoka, JP;
Yuki Iwayanagi, Shizuoka, JP;
Tatsuhiko Tachibana, Shizuoka, JP;
Futa Mimoto, Shizuoka, JP;
Taichi Kuramochi, Shizuoka, JP;
Hitoshi Katada, Shizuoka, JP;
Shojiro Kadono, Kanagawa, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The present invention demonstrated that the modification of the Fc region of an antigen-binding molecule into an Fc region that does not form in a neutral pH range a heterotetramer complex containing two molecules of FcRn and an active Fcγ receptor improved the pharmacokinetics of the antigen-binding molecule and reduced the immune response to the antigen-binding molecule. The present invention also revealed methods for producing antigen-binding molecules having the properties described above, and successfully demonstrated that pharmaceutical compositions containing as an active ingredient such an antigen-binding molecule or an antigen-binding molecule produced by a production method of the present invention have excellent features over conventional antigen-binding molecules in that when administered, they exhibit improved pharmacokinetics and reduced in vivo immune response.