The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 14, 2020

Filed:

Mar. 22, 2019
Applicant:

Metro International Biotech, Llc, Birmingham, MI (US);

Inventors:

Bruce Szczepankiewicz, Worcester, MA (US);

James M. McKearin, Worcester, MA (US);

Assignee:

Metro International Biotech, LLC, Birmingham, MI (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); C07H 19/048 (2006.01); A61K 45/06 (2006.01); A61K 31/706 (2006.01); A61K 9/20 (2006.01);
U.S. Cl.
CPC ...
C07H 19/048 (2013.01); A61K 31/706 (2013.01); A61K 45/06 (2013.01); A61K 9/20 (2013.01);
Abstract

The invention relates to compounds and compositions for modulation of nicotinamide adenine dinucleotide (NAD+). The invention also relates to methods of making such compounds and compositions. The invention relates to pharmaceutical compositions containing one or more NAD+ modulating compounds as a first ingredient in combination with one or more active pharmaceutical ingredients. Further, the invention relates to methods of using such compounds or compositions to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and/or improving cell and tissue survival.


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