The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Jun. 03, 2016
Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements
Applicant:
Promega Corporation, Madison, WI (US);
Inventors:
Sergiy Levin, Madison, WI (US);
Rachel Friedman Ohana, Madison, WI (US);
Thomas Kirkland, Madison, WI (US);
Keith V. Wood, Madison, WI (US);
Assignee:
PROMEGA CORPORATION, Madison, WI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/22 (2006.01); C07D 231/40 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 491/22 (2013.01); C07D 231/40 (2013.01); C07D 487/04 (2013.01);
Abstract
Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.