The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Nov. 21, 2014
Genmab A/s, Copenhagen V, DK;
Jesper Valbjørn, Veksø, DK;
Xiaona Jing, Soborg, DK;
Kelly Ann Roby, Bloomington, IN (US);
Timothy Warren Paul, Bloomington, IN (US);
Gregory Allan Sacha, Bargersville, IN (US);
Nathan Alan Pease, Bloomington, IN (US);
Bodil Willumsen, Basel, CH;
GENMAB A/S, Copenhagen V, DK;
Abstract
Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.