The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Dec. 29, 2017
Applicant:
Shimojani, Llc, San Francisco, CA (US);
Inventors:
Lawrence M. Kauvar, San Francisco, CA (US);
Damir Janigro, Cleveland Heights, OH (US);
Assignee:
Shimojani, LLC, San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/22 (2006.01); A61K 38/49 (2006.01); G01N 33/49 (2006.01); A61P 9/10 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 38/49 (2013.01); A61P 9/10 (2018.01); C07K 16/22 (2013.01); G01N 33/491 (2013.01); C12Y 304/21031 (2013.01); C12Y 304/21068 (2013.01); C12Y 304/21073 (2013.01);
Abstract
Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (VEGF-RST) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity.