The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Aug. 21, 2013
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
Pengbo Zhou, Princeton Junction, NJ (US);
J. David Warren, New York, NY (US);
Assignee:
CORNELL UNIVERSITY, Ithaca, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); A61K 31/382 (2006.01); A61K 31/39 (2006.01); A61K 31/4196 (2006.01); A61K 31/425 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/4704 (2006.01); A61K 31/423 (2006.01); A61K 31/426 (2006.01); A61K 31/44 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4709 (2013.01); A61K 31/382 (2013.01); A61K 31/39 (2013.01); A61K 31/4196 (2013.01); A61K 31/423 (2013.01); A61K 31/425 (2013.01); A61K 31/426 (2013.01); A61K 31/44 (2013.01); A61K 31/4704 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01);
Abstract
The invention is directed to a method of treating a cancer in an animal and a method of increasing DNA repair activity in an animal. The methods comprise administering to an animal in need thereof an effective amount of a small molecule substance that interferes with the activity of CUL4A, such as a 1,3-benzoxathiol-2-one compound, a pyridine thione compound, a 2,6-diamino-4-thiopyran-3,5-dicarbonitrile compound, or a 1,2,4-triazole-3-thiol compound.