The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2020
Filed:
Apr. 12, 2019
Applicant:
Jingluweidai Information Consulting Service (Beijing) Co. Ltd., Beijing, CN;
Inventors:
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4745 (2006.01); A61K 31/4375 (2006.01); A61P 25/30 (2006.01); C07D 471/04 (2006.01); A61P 25/04 (2006.01); A61P 25/00 (2006.01); C07D 455/03 (2006.01); A61P 25/32 (2006.01); A61P 25/34 (2006.01); A61P 25/18 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4375 (2013.01); A61K 31/4745 (2013.01); A61P 25/00 (2018.01); A61P 25/04 (2018.01); A61P 25/18 (2018.01); A61P 25/30 (2018.01); A61P 25/32 (2018.01); A61P 25/34 (2018.01); C07D 455/03 (2013.01); C07D 471/04 (2013.01);
Abstract
The present disclosure relates to a compound of Formula I or a non-toxic pharmaceutically acceptable salt or solvate thereof, wherein each R1, R2, R3, and R4 is independently selected from methyl (—CH) and trideuteromethyl (—CD), at least one of R1, R2, R3, and R4 is selected from trideuteromethyl (—CD). The compound is a deuterated derivative of L-tetrahydropalmatine, which not only markedly improves pharmacological effects, but also significantly reduces cardiac side effects, liver toxicity, and remarkably decreases individual differences.