The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Feb. 18, 2016
Applicant:
Ncardia B.v., Leiden, NL;
Inventors:
Stefan Robbert Braam, Leiden, NL;
Fleur Stevenhagen, Leiden, NL;
Assignee:
NCARDIA B.V., Leiden, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
G01N 33/5014 (2013.01); C12N 5/0657 (2013.01); G01N 33/5061 (2013.01);
Abstract
The current disclosure relates to technology for predicting cardiotoxicity of compounds. In vitro methods using human stem-cell derived cardiomyocytes cultured in specific media are disclosed, as well as kits for use in the method. In the method, the cells are treated with a test compound in combination with a mitochondrial toxicant.