The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 07, 2020

Filed:

Dec. 12, 2016
Applicant:

Cornell Research Foundation, Inc., Ithaca, NY (US);

Inventor:

Manikkam Suthanthiran, Scarsdale, NY (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6876 (2018.01); A61K 31/56 (2006.01); G01N 33/68 (2006.01); C07K 16/28 (2006.01); A61K 35/14 (2015.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6876 (2013.01); A61K 31/56 (2013.01); A61K 35/14 (2013.01); C07K 16/28 (2013.01); C07K 16/2809 (2013.01); G01N 33/6872 (2013.01); G01N 33/6893 (2013.01); A61K 2039/505 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01); G01N 2333/4703 (2013.01); G01N 2800/245 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01);
Abstract

A method for assessing risk of losing a transplanted organ by a patient having an episode of acute rejection of the transplanted organ is described. The method includes obtaining from the patient a cell sample from the transplanted organ or peripheral blood, determining a level of FOXP3 in the cell sample, and correlating the level with the risk of loss of the transplanted organ, wherein, compared to a control level, a significantly greater level of FOXP3 in the cell sample from the transplanted organ or a significantly lower level of FOXP3 in the cell sample from the peripheral blood correlates with a decreased risk of loss of the transplanted organ.


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