The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 07, 2020

Filed:

Dec. 09, 2015
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Karen Christman, San Diego, CA (US);

Gregory Grover, Carlsbad, CA (US);

Michael Madani, La Jolla, CA (US);

Masaki Fujita, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08G 65/48 (2006.01); A61L 31/14 (2006.01); A61L 24/00 (2006.01); C08J 3/24 (2006.01); C08J 3/075 (2006.01); C08F 16/06 (2006.01); C08B 37/02 (2006.01); C08B 37/08 (2006.01);
U.S. Cl.
CPC ...
C08G 65/48 (2013.01); A61L 24/0031 (2013.01); A61L 31/145 (2013.01); C08F 16/06 (2013.01); C08J 3/075 (2013.01); C08J 3/246 (2013.01); C08B 37/0021 (2013.01); C08B 37/0072 (2013.01); C08G 2650/50 (2013.01); C08J 2300/206 (2013.01); C08J 2371/02 (2013.01); C08J 2400/206 (2013.01); C08J 2471/02 (2013.01);
Abstract

Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.


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