The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
May. 26, 2017
Applicant:
Ucl Business Ltd, London, GB;
Inventors:
Martin Pulé, London, GB;
Kwee Yong, London, GB;
Lydia Lee, London, GB;
Neil Chaplin, London, GB;
Ben Draper, London, GB;
Assignee:
UCL BUSINESS LTD, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 14/525 (2006.01); C07K 14/725 (2006.01); A61K 35/17 (2015.01); C12N 15/85 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 14/525 (2013.01); A61K 35/17 (2013.01); C07K 14/7051 (2013.01); C12N 15/85 (2013.01); G01N 33/57407 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/70 (2013.01); G01N 2333/70575 (2013.01); G01N 2800/22 (2013.01);
Abstract
The present invention provides a variant proliferation-inducing ligand (APRIL), which has a higher binding affinity to BCMA than wild-type APRIL; and/or altered binding kinetics compared with wild-type APRIL, and/or a higher BCMA:TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) binding ratio than wild-type APRIL and which comprises mutations at one or more of the following positions: A125, V174, T175, M200, P201, S202, H203, D205 and R206.