The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 07, 2020

Filed:

Jan. 31, 2008
Applicants:

Paul O. Zamora, Gaithersburg, MD (US);

Louis A. Pena, Poquott, NY (US);

Xinhua Lin, Plainview, NY (US);

Kazuyuki Takahashi, Germantown, MD (US);

Inventors:

Paul O. Zamora, Gaithersburg, MD (US);

Louis A. Pena, Poquott, NY (US);

Xinhua Lin, Plainview, NY (US);

Kazuyuki Takahashi, Germantown, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C07H 21/04 (2006.01); A61L 27/34 (2006.01); C07K 14/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 38/1709 (2013.01); A61K 38/1875 (2013.01); A61L 27/34 (2013.01); C07H 21/04 (2013.01); C07K 14/503 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.


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