The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Mar. 09, 2017
Applicant:
Pfizer Inc., New York, NY (US);
Inventors:
Xinzhen Yang, Woodcliff Lake, NJ (US);
Xiaoyuan Sherry Chi, Tenafly, NJ (US);
Assignee:
Pfizer Inc., New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01); A61K 39/245 (2006.01); A61P 31/20 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/245 (2013.01); A61P 31/20 (2018.01); C12N 2710/16122 (2013.01); C12N 2710/16134 (2013.01); C12N 2710/16171 (2013.01);
Abstract
The present invention relates to a polypeptide that includes at least one mutation in the fusion loop 1 region and/or in the fusion loop 2 region and/or in the furin-like cleavage site of a human cytomegalovirus gB polypeptide. In one embodiment, the polypeptide undergoes a structural conformation change in response to pH change.