The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Sep. 25, 2014
Applicant:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Inventors:
Glen Bolton, Boston, MA (US);
Keith Selvitelli, Sutton, MA (US);
Assignee:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 2/00 (2006.01); A61K 38/00 (2006.01); A61K 35/16 (2015.01); A61K 35/14 (2015.01); C07K 1/22 (2006.01); C07K 16/06 (2006.01); C07K 1/16 (2006.01); C07K 14/755 (2006.01);
U.S. Cl.
CPC ...
C07K 1/22 (2013.01); A61L 2/0088 (2013.01); C07K 1/165 (2013.01); C07K 14/755 (2013.01); C07K 16/065 (2013.01); A61L 2202/21 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.