The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Apr. 17, 2019
Applicant:
Eli Lilly and Company, Indianapolis, IN (US);
Inventors:
Darryl Wayne Hilliard, Fishers, IN (US);
Junliang Hao, Carmel, IN (US);
David Andrew Coates, New Palestine, IN (US);
Assignee:
Eli Lilly and Company, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 217/06 (2006.01); C07D 401/06 (2006.01); A61K 31/4725 (2006.01); C07D 401/04 (2006.01); A61P 25/18 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/28 (2018.01); C07B 2200/13 (2013.01);
Abstract
The invention provides certain (phenyl)-(pyrazol)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one compounds of formula I as D1 positive allosteric modulators (PAMs), and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I, or a pharmaceutically acceptable salt thereof, to treat certain symptoms of Parkinson's disease, schizophrenia, ADHD or Alzheimer's disease.