The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Mar. 20, 2018
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Barry Forman, Irvine, CA (US);
Donna Yu, Arcadia, CA (US);
Assignee:
CITY OF HOPE, Duarte, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/14 (2006.01); C07D 231/12 (2006.01);
U.S. Cl.
CPC ...
C07D 231/14 (2013.01); C07D 231/12 (2013.01);
Abstract
Provided herein are Famesoid X receptor (FXR) antagonists having the structure of formula (I), and pharmaceutical compositions comprising the compound of formula (I) and a pharmaceutically acceptable excipient. Also provided are methods of antagonizing FXR, and methods of treating metabolic disease in a subject in need thereof, comprising administering an effective amount of the FXR antagonists of formula (I) to a subject.