The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Oct. 18, 2018
Hangzhou Normal University, Hangzhou, CN;
Hangzhou Loop Biotech Co., Ltd, Hangzhou, CN;
Weiming Xu, Hangzhou, CN;
Pengfei Zhang, Hangzhou, CN;
Dongxiang Feng, Hangzhou, CN;
Lianzhi Tao, Hangzhou, CN;
HANGZHOU NORMAL UNIVERSITY, Hangzhou, CN;
HANGZHOU LOOP BIOTECH CO., LTD, Hangzhou, CN;
Abstract
The present invention provides a method for preparing levobunolol hydrochloride. In the present invention S-1-tert-butyl-epoxy methylamine is subjected to a substitution reaction with 5-hydroxy-1-tetralone, and acidified to obtain the target product levobunolol hydrochloride. The method provided by the present invention greatly improves the regioselectivity of the reaction, avoids the occurrence of side reactions, and effectively improves the yield and optical purity of levobunolol hydrochloride, with the yield being 87.3%, and the ee value being over 99%.