The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2020
Filed:
Jun. 20, 2017
International Business Machines Corporation, Armonk, NY (US);
Agency for Science, Technology and Research, Singapore, SG;
Universidad Del Paìs Vasco/euskal Herriko Unibertsitatea, Bizkaia, ES;
Julian M. W. Chan, Fremont, CA (US);
Amanda C. Engler, San Jose, CA (US);
James L. Hedrick, Pleasanton, CA (US);
Haritz Sardon, San Jose, CA (US);
Jeremy P. K. Tan, Singapore, SG;
Yi Yan Yang, Singapore, SG;
International Business Machines Corporation, Armonk, NY (US);
Agency For Science, Technology And Research, Singapore, SG;
Universidad del Pais Vasco/Euskal Herriko Unibersitatea, Bizkaia, ES;
Abstract
Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.