The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 07, 2020

Filed:

Jan. 24, 2019
Applicant:

Abic Biological Laboratories Ltd., Beit Shemesh, IL;

Inventor:

Noel Yves Henri Jean Genin, Saint Genis les Ollieres, FR;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/26 (2006.01); A61K 9/46 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/17 (2006.01); A61K 39/215 (2006.01); A61K 39/255 (2006.01); A61K 39/275 (2006.01);
U.S. Cl.
CPC ...
A61K 47/26 (2013.01); A61K 9/0007 (2013.01); A61K 9/0056 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2063 (2013.01); A61K 39/00 (2013.01); A61K 39/12 (2013.01); A61K 39/17 (2013.01); A61K 39/215 (2013.01); A61K 39/255 (2013.01); A61K 39/275 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/552 (2013.01); C12N 2760/18134 (2013.01); C12N 2770/20034 (2013.01);
Abstract

Disclosed and claimed are methods for making solid vaccine compositions that have reduced foaming when mixed with liquid diluent. The methods include mixing an effective amount of a foam controlling agent with at least one anhydrous antigenic component, a stabilizer, and an effervescent agent. The foam controlling agent is a sugar alcohol, such as mannitol. The effective amount of sugar alcohol is about 15% to about 40% by weight of the solid vaccine composition. And, upon adding a diluent to the solid vaccine composition, the effervescent agent reacts to form gas in situ, and foam resulting from the gas is reduced.


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