The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Feb. 02, 2018
Thermo Fisher Scientific (Bremen) Gmbh, Bremen, DE;
Jens Griep-Raming, Ganderkesee, DE;
Thermo Fisher Scientific (Bremen) GmbH, Bremen, DE;
Abstract
A method of isotope ratio mass spectrometry comprising: flowing a liquid mobile phase through a separation device; reducing the flow rate of the mobile phase through the separation device for at least a portion of time that at least one molecular species is emerging from the separation device to achieve a desired isotope ratio precision, wherein the flow rate is reduced from a first rate to a second rate corresponding to a higher theoretical plate height of the separation device; and mass analyzing the molecular species that has emerged from the separation device at least while the flow rate is reduced; and determining at least one isotope ratio from the intensities of mass peaks of at least two isotopologues, wherein the mass analysis is performed with mass resolving power high enough to resolve the two most abundant mass peaks at the nominal mass of at least one of the isotopologues.