The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 31, 2020

Filed:

Jan. 19, 2018
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Matthew Rosen, Somerville, MA (US);

Christian T. Farrar, Arlington, MA (US);

Ouri Cohen, Teaneck, NJ (US);

Shuning Huang, College Station, TX (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01R 33/50 (2006.01); G01R 33/48 (2006.01); G01R 33/56 (2006.01);
U.S. Cl.
CPC ...
G01R 33/50 (2013.01); G01R 33/4824 (2013.01); G01R 33/5605 (2013.01); G01R 33/4804 (2013.01);
Abstract

A system and method of use includes (a) directing a magnetic resonance (MR) system to perform a pulse sequences block in which radio frequency (RF) energy is applied to the subject to substantially saturate magnetization corresponding to an exchangeable proton. The method includes (b), following step (a), acquiring data from the subject with the MR system and (c) repeating step (a) a plurality of times where parameters of the pulse sequence sub-block differ in at least some pulse sequence sub-blocks by at least an amount of RF energy applied to saturate the magnetization. The method further includes (d), after each repetition of step (a), repeating step (b) to acquire data representing signal evolutions from the subject. Additionally, the method includes (e) comparing the signal evolutions with a dictionary database comprising a plurality of different signal evolution templates to determine quantitative chemical exchange or exchangeable proton information of the subject.


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