The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Mar. 13, 2018
Applicant:
Turnstone Limited Partnership, Toronto, CA;
Inventors:
Carolina Solange Ilkow, Ottawa, CA;
Fabrice Le Boeuf, Gatineau, CA;
John Cameron Bell, Ottawa, CA;
Jean-Simon Diallo, Ottawa, CA;
Rozanne Arulanandam, Orleans, CA;
Assignee:
TURNSTONE LIMITED PARTNERSHIP, Toronto, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2020.01); A61K 35/76 (2015.01); A61K 35/766 (2015.01); A61K 35/768 (2015.01); A61K 38/17 (2006.01); C12N 7/00 (2006.01); C07K 14/50 (2006.01); A61K 38/18 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 35/76 (2013.01); A61K 35/766 (2013.01); A61K 35/768 (2013.01); A61K 38/1793 (2013.01); A61K 38/1825 (2013.01); C07K 14/50 (2013.01); C07K 2319/02 (2013.01); C12N 2710/16651 (2013.01); C12N 2710/24151 (2013.01); C12N 2720/12051 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/16152 (2013.01); C12N 2760/18451 (2013.01); C12N 2760/18452 (2013.01); C12N 2760/20232 (2013.01); C12N 2760/20251 (2013.01); Y02A 50/385 (2018.01); Y02A 50/393 (2018.01); Y02A 50/465 (2018.01);
Abstract
Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.