The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
May. 14, 2014
Applicant:
Carsgen Therapeutics Limited, Shanghai, CN;
Inventors:
Zonghai Li, Shanghai, CN;
Huiping Gao, Shanghai, CN;
Hua Jiang, Shanghai, CN;
Bizhi Shi, Shanghai, CN;
Assignee:
CarsGEN Therapeutics Limited, Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/16 (2006.01); C12N 7/00 (2006.01); C12N 15/62 (2006.01); C07K 14/71 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
C12N 5/163 (2013.01); C07K 14/7051 (2013.01); C07K 14/70503 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/71 (2013.01); C12N 7/00 (2013.01); C12N 15/62 (2013.01); C12N 2740/15043 (2013.01);
Abstract
A nucleic acid for coding a chimeric antigen receptor protein expressed on the surface of a human T lymphocyte. The chimeric antigen receptor protein comprises an extracellular binding domain, a transmembrane domain and an intracellular signal domain that are orderly connected. The extracellular binding domain comprises a single-chain antibody scFv (EGFR) for specific recognition of 287to 302amino acid epitopes of a human epidermal growth factor receptor (EGFR).