The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Jan. 04, 2017
Applicant:
Colorado State University Research Foundation, Fort Collins, CO (US);
Inventors:
Brian R. McNaughton, Fort Collins, CO (US);
Virginia J. Bruce, Fort Collins, CO (US);
Assignee:
Colorado State University Research Foundation, Fort Collins, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); G01N 33/531 (2006.01); G01N 33/532 (2006.01); G01N 33/533 (2006.01); C07K 16/40 (2006.01); C07K 16/32 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); G01N 33/53 (2013.01); G01N 33/531 (2013.01); G01N 33/532 (2013.01); G01N 33/533 (2013.01); C07K 2317/567 (2013.01); C07K 2317/569 (2013.01); C07K 2317/77 (2013.01);
Abstract
The disclosure encompasses resurfaced cell-penetrating nanobodies and their methods of use. The resurfacing of nanobodies with positively-charged amino acids facilitates their penetration into a cell and allows targeting of a specific intracellular protein.