The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Aug. 01, 2018
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Craig S. Siegel, Woburn, MA (US);
Rayomand Gimi, Bridgewater, NJ (US);
Michael Reardon, North Attleboro, MA (US);
Jin Zhao, Framingham, MA (US);
Assignee:
GENZYME CORPORATION, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 453/00 (2006.01); C07D 453/02 (2006.01); C07D 417/06 (2006.01); C07D 277/30 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 453/02 (2013.01); C07D 277/30 (2013.01); C07D 417/06 (2013.01); C07D 417/12 (2013.01);
Abstract
The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.