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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10604509 B1

PDFFull Text
Date of Patent:
Mar. 31, 2020

Filed:

Jun. 15, 2016

Nrf2 regulators

Applicants:

Glaxosmithkline Intellectual Property Development Limited, Brentford, Middlesex, GB;

Astex Therapeutics, Limited, Milton Road, Cambridge, GB;

Inventors:

Jeffrey K. Kerns, King of Prussia, PA (US);

James Callahan, King of Prussia, PA (US);

Thomas Daniel Heightman, Harpenden, GB;

Alison Jo-Anne Woolford, Cambridge, GB;

Ami Lakdawala Shah, Collegeville, PA (US);

Roderick S. Davis, King of Prussia, PA (US);

David Norton, Cambridge, GB;

Jeffrey Charles Boehm, King of Prussia, PA (US);

Nicole Cathleen Goodwin, King of Prussia, PA (US);

Assignees:

GlaxoSmithKline Intellectual Property Development Limited, Brentford, Middlesex, GB;

Astex Therapeutics Limited, Cambridge, Cambridgeshire, GB;

Attorneys:

Nora L. Stein

Fang Qian

Edward R. Gimmi

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07D 417/10 (2006.01); C07D 403/10 (2006.01); C07D 249/04 (2006.01); C07D 249/18 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/10 (2006.01); C07D 403/14 (2006.01); C07D 413/10 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 267/14 (2006.01); C07D 233/60 (2006.01); C07D 487/08 (2006.01); C07D 451/02 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61P 11/00 (2006.01); A61P 27/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07D 233/64 (2006.01); C07D 255/04 (2006.01); C07D 273/01 (2006.01); C07D 405/10 (2006.01);
U.S. Cl.
CPC ...
C07D 403/10 (2013.01); A61P 9/00 (2018.01); A61P 11/00 (2018.01); A61P 25/00 (2018.01); A61P 27/00 (2018.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01); C07D 233/60 (2013.01); C07D 233/64 (2013.01); C07D 249/18 (2013.01); C07D 255/04 (2013.01); C07D 267/14 (2013.01); C07D 273/01 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/10 (2013.01); C07D 405/14 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 451/02 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 498/04 (2013.01);
Abstract

Provided are aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.

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