The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Jun. 13, 2017
Applicant:
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Inventors:
Arnaud Chevalier, La ville-du-Bois, FR;
Omar Khdour, Phoenix, AZ (US);
Yanmin Zhang, Tempe, AZ (US);
Sidney Hecht, Phoenix, AZ (US);
Assignee:
Arizona Board of Regents on behalf of Arizona State University, Scottsdale, AZ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 321/00 (2006.01); C07D 311/06 (2006.01); C07D 311/58 (2006.01); C07D 403/08 (2006.01); C07D 405/04 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); C07D 487/14 (2006.01); C07D 493/10 (2006.01); A61K 47/54 (2017.01); A61K 49/00 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
C07D 321/00 (2013.01); C07D 311/06 (2013.01); C07D 311/58 (2013.01); C07D 403/08 (2013.01); C07D 405/04 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 487/14 (2013.01); C07D 493/10 (2013.01); A61K 47/545 (2017.08); A61K 49/0052 (2013.01); G01N 33/582 (2013.01);
Abstract
The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.