The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 31, 2020

Filed:

Dec. 12, 2018
Applicants:

The United States of America As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Yale University, New Haven, CT (US);

Inventors:

John Schneekloth, Jr., Frederick, MD (US);

John Simmons, Bethesda, MD (US);

Kenneth Felsenstein, Bethesda, MD (US);

Beverly Mock, Bethesda, MD (US);

Lindsey Saunders, Frederick, MD (US);

David Calabrese, Frederick, MD (US);

Elena Leon, Bethesda, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/84 (2006.01); A61K 31/343 (2006.01); A61P 35/00 (2006.01); A61K 31/397 (2006.01); A61K 31/4025 (2006.01); A61K 31/439 (2006.01); A61K 31/4525 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 405/06 (2006.01); C07D 471/08 (2006.01);
U.S. Cl.
CPC ...
C07D 307/84 (2013.01); A61K 31/343 (2013.01); A61K 31/397 (2013.01); A61K 31/4025 (2013.01); A61K 31/439 (2013.01); A61K 31/4525 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 405/06 (2013.01); C07D 471/08 (2013.01);
Abstract

Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.


Find Patent Forward Citations

Schneekloth, Jr., John. (2020). Myc g-quadruplex stabilizing small molecules and their use (U.S. Patent No. 10604499). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10604499

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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