The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Nov. 16, 2016
Applicant:
Roche Glycart Ag, Schlieren, CH;
Inventors:
Christian Gerdes, Erlenbach, CH;
Christian Klein, Bonstetten, CH;
Valeria G. Nicolini, Erlenbach, CH;
Pablo Umana, Wollerau, CH;
Assignee:
Roche Glycart AG, Schlieren, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
A61K 38/2013 (2013.01); A61K 45/06 (2013.01); A61K 47/642 (2017.08); A61K 47/6849 (2017.08); A61K 47/6853 (2017.08); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C07K 16/3007 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/41 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/732 (2013.01);
Abstract
The present invention provides combinations of (a) an immunoconjugate comprising a first antibody engineered to have reduced effector function and an effector moiety, and (b) a second antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.