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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10603313 B1

PDFFull Text
Date of Patent:
Mar. 31, 2020

Filed:

Jul. 27, 2018

Allosteric modulators of the mu opioid receptor

Applicant:

Chiromics, Llc, Princeton, NJ (US);

Inventors:

Joel Francis Austin, West Windsor, NJ (US);

Michael David VanHeyst, Morrisville, PA (US);

James S. Harvey, Brookline, MA (US);

Elizabeth Gerig Rowley, Kendall Park, NJ (US);

Christophe Lamarque-Lacoste, Princeton, NJ (US);

Assignee:

CHIROMICS, LLC, Princeton, NJ (US);

Attorney:

Brennan IP Services

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A61K 31/451 (2006.01); A61K 31/4545 (2006.01); A61K 38/07 (2006.01); A61P 25/04 (2006.01); C07D 401/06 (2006.01); C07D 401/04 (2006.01); A61K 31/439 (2006.01); C07D 401/12 (2006.01); C07D 211/96 (2006.01); C07D 401/14 (2006.01); C07D 221/22 (2006.01); A61K 31/506 (2006.01); A61K 38/17 (2006.01); C07D 209/52 (2006.01); C07D 207/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4545 (2013.01); A61K 31/439 (2013.01); A61K 31/506 (2013.01); A61K 38/07 (2013.01); A61K 38/1787 (2013.01); A61P 25/04 (2018.01); C07D 207/48 (2013.01); C07D 209/52 (2013.01); C07D 211/96 (2013.01); C07D 221/22 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01);
Abstract

Disclosed herein are compounds, of the class of amine-bearing heterocycles, which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. These compounds are useful for the treatment of pain, drug addiction, and other CNS derived maladies that are controlled directly or indirectly by activation of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.

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