The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
Jul. 03, 2015
Applicants:
Medical Research Council, Wiltshire, GB;
Cambridge Enterprise Limited, Cambridge, GB;
Inventors:
Edward Chouchani, Cambridge, GB;
Thomas Krieg, Cambridge, GB;
Michael Patrick Murphy, Cambridge, GB;
Lorraine Work, Glasgow, GB;
Christian Frezza, Cambridge, GB;
Kourosh Saeb-Parsy, Cambridge, GB;
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/225 (2006.01);
U.S. Cl.
CPC ...
A61K 31/225 (2013.01); A61K 31/225 (2013.01); A61K 2300/00 (2013.01);
Abstract
The invention relates to a succinate dehydrogenase inhibitor or a prodrug and/or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of reperfusion injury, such as ischemia-reperfusion injury, by inhibiting the accumulation of succinate, wherein the inhibitor or prodrug and/or pharmaceutically acceptable salt thereof is a cell-permeable reversible inhibitor of succinate dehydrogenase.