The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2020
Filed:
May. 15, 2018
Danmarks Tekniske Universitet, Lyngby, DK;
Thomas Bjarnsholt, Søborg, DK;
Niels Høiby, Farum, DK;
Peter Østrup Jensen, Copenhagen S, DK;
Richard Phipps, Boston, GB;
Meenakshi Sundaram Shanmugham, Copenhagen N, DK;
Maria Alhede, Greve, DK;
Louise Dahl Hultqvist, Kgs. Lyngby, DK;
Tim Holm Jakobsen, Copenhagen S, DK;
David Tanner, Copenhagen N, DK;
Thomas Ostenfeld Larsen, Holte, DK;
Michael Givskov, Humlebæk, DK;
DANMARKS TEKNISKE UNIVERSITET, Lyngby, DK;
Abstract
The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C═C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.