The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2020
Filed:
Oct. 20, 2017
Applicants:
Jeffrey Millman, St. Louis, MO (US);
Jiwon Song, St. Louis, MO (US);
Inventors:
Jeffrey Millman, St. Louis, MO (US);
Jiwon Song, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61F 2/02 (2006.01); A61K 35/39 (2015.01); A61K 45/06 (2006.01); A61L 27/38 (2006.01); C12N 5/0775 (2010.01); A61P 5/50 (2006.01); C08F 220/14 (2006.01); B33Y 80/00 (2015.01); C08F 220/28 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0677 (2013.01); A61F 2/02 (2013.01); A61K 35/39 (2013.01); A61K 45/06 (2013.01); A61L 27/3834 (2013.01); A61L 27/3895 (2013.01); A61P 5/50 (2018.01); B33Y 80/00 (2014.12); C08F 220/14 (2013.01); C08F 220/28 (2013.01); C12N 5/0662 (2013.01); C12N 5/0676 (2013.01); A61F 2/022 (2013.01); A61F 2240/001 (2013.01); C12N 2506/02 (2013.01); C12N 2506/1369 (2013.01); C12N 2506/1392 (2013.01); C12N 2506/22 (2013.01); C12N 2513/00 (2013.01); C12N 2533/30 (2013.01);
Abstract
Disclosed herein is a 3D-printed, biocompatible macroporous device that houses stem cell derived β-cell (SC-β cell) clusters within a degradable fibrin gel. Cluster sizes are used that avoid severe hypoxia within 3D-printed devices and a microwell-based technique is used for resizing clusters within this range. 3D-printed devices may function for at least 12 weeks, are retrievable, and maintain structural integrity.