The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2020
Filed:
Nov. 11, 2016
The Johns Hopkins University, Baltimore, MD (US);
Hongjun Song, Clarksville, MD (US);
Guoli Ming, Clarksville, MD (US);
Mingxi Max Song, Clarksville, MD (US);
Christopher Hadiono, Armonk, NY (US);
William Jeang, Houston, TX (US);
Ha Nam Nguyen, Baltimore, MD (US);
Xuyu Qian, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
A cell culture system and method of generating organoids is provided. The system includes a multiwell culture plate having shafts for mixing culture media within wells of the culture plate. The multiwell culture plate includes a base substrate having a plurality of culture wells, and a shaft operably associated with each culture well, each shaft being configured to mix media present in each culture well and having a gear adapted to operably associate with a gear on a shaft associated with an adjacent culture well. The system further includes a motor having a drive shaft in operable communication with the shaft gears of the multiwell culture plate. The system can be widely used as a standard platform to generate stem cell-derived human organoids for any tissue and for high-throughput drug screenings, toxicity testing, and modeling normal human organ development and diseases.