The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2020

Filed:

Nov. 13, 2017
Applicant:

Adc Therapeutics SA, Epalinges, CH;

Inventors:

Gilles Bernard Tremblay, La Prairie, CA;

Anna N. Moraitis, Laval, CA;

Traian Sulea, Kirkland, CA;

Mario Filion, Longueuil, CA;

Assignee:

ADC Therapeutics SA, Epalinges, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); G01N 33/574 (2006.01); C07K 16/30 (2006.01); C07K 16/00 (2006.01); A61K 38/06 (2006.01); A61K 45/06 (2006.01); C07K 16/18 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 38/06 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61K 47/6861 (2017.08); A61K 47/6869 (2017.08); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C07K 16/30 (2013.01); C07K 16/3038 (2013.01); C07K 16/3069 (2013.01); G01N 33/57484 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/92 (2013.01);
Abstract

Novel antibodies and antigen binding fragments that specifically bind to KAAG1 and which may be used in the treatment, detection and diagnosis of cancer comprising KAAG1-expressing cells are disclosed herein. Cells expressing the antibodies and antigen binding fragments as well as methods of detecting and treating cancer using the antibodies and fragments are also disclosed. Cancer indications which may benefit from such treatment or detection include ovarian cancer, renal cancer, lung cancer, colorectal cancer, breast cancer, brain cancer, and prostate cancer, as well as melanomas.


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